Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise
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چکیده
منابع مشابه
Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise.
An active lifestyle is crucial to maintain health into old age; inversely, sedentariness has been linked to an elevated risk for many chronic diseases. The discovery of myokines, hormones produced by skeletal muscle tissue, suggests the possibility that these might be molecular mediators of the whole body effects of exercise originating from contracting muscle fibers. Even though less is known ...
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Tropism and efficiency of skeletal muscle depend on the complex balance between anabolic and catabolic factors. This balance gradually deteriorates with aging, leading to an age-related decline in muscle quantity and quality, called sarcopenia: this condition plays a central role in physical and functional impairment in late life. The knowledge of the mechanisms that induce sarcopenia and the a...
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Skeletal muscle is adapting to the needs of the body by changes of various gene expression that control mitochondrial biogenesis, angiogenesis, and the composition of muscle fiber types. Recently, it was revealed that PGC-1α, which is an auxiliary transcription factor, plays a key role in the aforementioned adaptation phenomena. It means that various signal transduction systems within muscle di...
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Skeletal muscle is an endocrine organ that produces and releases myokines in response to contraction. Some myokines are likely to work in a hormone-like fashion, exerting specific endocrine effects on other organs such as the liver, the brain, and the fat. Other myokines will work locally via paracrine mechanisms, exerting, e.g., angiogenetic effects, whereas yet other myokines work via autocri...
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ژورنال
عنوان ژورنال: Bone
سال: 2015
ISSN: 8756-3282
DOI: 10.1016/j.bone.2015.02.008